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Publications

• Pearson S, Loft A, Rahbhandari P, Simcox J, Lee S, Donato A, Tontonoz P, Mandrup S, and CJ Villanueva. TLE3 attenuates mitochondrial gene expression in beige adipocytes through repression of EBF2. 2019. Genes and Development. 33(13-14):747-762.
• Begaye L and JA Simcox. Intramuscular adipocytes: a buried adipose tissue depot deserving more exploration. 2019. Journal of Lipid Research. 60(4):753-754.
• Geoghegan G*, Simcox J*, Seldin M, Parnell T, Stubben C, Just S, Begaye L, Lusis A, and CJ Villanueva. Targeted deletion of diabetes risk gene Tcf7L2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism. 2019. Molecular Metabolism. 24:44-63.
*indicates co-first authorship
• Storelli G, Nam H, Simcox J, Villanueva CJ and CS Thummel. Drosophila Hepatocyte Nuclear Factor 4 directs a switch in lipid metabolism that supports the transition to adulthood. 2018. Dev Cell. 28;48(2):200-214.
• Karanth S, Adams JD, Serrano Mde L, Quittner-Strom E, Simcox J, Villanueva CJ, Ozcan L, Holland WL, Yost HJ, Vella A, and A Schlegel. A hepatocyte FOXN3-α-cell glucagon axis regulates fasting glucose. 2018. Cell Reports. 10;24(2):312-319.
• Sommakia S, Houlihan PR, Deane SS, Simcox JA, Torres NS, Jeong MY, Winge DR, Villanueva CJ, and D Chaudhuri. Mitochondrial cardiomyopathies feature a compensatory increase in mitochondrial calcium signaling. 2017. J of Mol Cell Cardiol. 113:22-32.
Simcox JA, Geoghegan G, Machek JA, Bensard CL, Pasquali M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Long N, Rutter J, Schreiber R, Zechner R, Cox J, and CJ Villanueva. Global analysis of plasma lipids identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis. 2017.Cell Metabolism. 5;26(3):509-522.e6.
*Featured as Cover Story http://sacnas.org/2017/09/19/diversityinclusion-front-and-center-in-cell-metabolism-thanks-to-sacnas-members-dr-villanueva-and-dr-simcox/
*Reviewed by: https://www.cell.com/cell-metabolism/abstract/S1550-4131(17)30503-X
*Featured in: https://www.medicalnewstoday.com/articles/319291.php
• Gao Y, Li Z, Gabrielsen JS, Simcox JA, Lee S, Jones D, Cooksey RC, Stoddard G, Cefalu W, and DA McClain. Adipocyte iron regulates leptin and food intake. 2015. JCI. 125(9):3681-91.
Simcox JA, Mitchell CM, Gao Y, Just SF, Lee S, Jones D, Cooksey B, Cox J, King D, Huang J, and DA McClain. Dietary iron controls circadian rhythm of hepatic glucose metabolism through heme synthesis. 2014. Diabetes. 64(4):1108-19.
*Featured in: http://www.safetyandhealthmagazine.com/articles/11910-exploring-shift-worker-health
http://www.ehstoday.com/health/shift-workers-might-want-skip-high-iron-foods-night
*Commented on: http://diabetes.diabetesjournals.org/content/64/4/1091
Simcox JA, DA McClain. Review article: Iron and diabetes risk. 2013. Cell metabolism. 17(3):329-41.
• Huang J, Simcox JA, Jones D, Cox J, Luo B, Cooksey RC, Boros LG, and DA McClain. Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice. 2013. FASEB. 27(7):2845-54.
• McClain DA, Abuelgasim KA, Nouraie M, Salomon-Andonie J, Niu X, Miasnikova G, Polyakova LA, Sergueeva A, Okhotin DJ, Cherqaoui R, Okhotin D, Cox JE, Swierczek S, Song J, Simon MC, Huang J, Simcox JA, Yoon D, Prchal JT, Gordeuk VR. Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism. 2012. J Mol Med (Berl). 91(1):59-67.
• Gabrielsen JS, Gao Y, Simcox JA, Huang J, Thorup D, Jones D, Cooksey RC, Gabrielsen D, Adams TD, Hunt SC, Hopkins PN, Cefalu WT, McClain DA. Adipocyte iron regulates adiponectin and insulin sensitivity. 2012. JCI. 122(10):3529-40.
• Kusminski CM, Holland WL, Sun K, Park J, Spurgin SB, Lin Y, Askew GR, Simcox JA, McClain DA, Li C, Scherer PE. MitoNEET- driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. 2012. Nature Medicine. 18(10):1539-49.
• Cooksey RC, Jones D, Gabrielsen S, Huang J, Simcox JA, Luo B, Soesanto Y, Rienhoff H, Abel ED, McClain DA. Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse. 2010. Am J Physiol Endocrinol Metab. 298(6):1236-1243.
• Shields GF, Pickens JA, Clausen GM, Strizich LM. Reproductive Status of Cytoforms in a Black Fly Complex in Montana. 2007. Intermountain Journal of Sciences. 13(1):511–520.

Total publications